Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis
نویسندگان
چکیده
Interleukin-1 has been implicated as a mediator of recurrent pericarditis. The efficacy and safety rilonacept, an interleukin-1α interleukin-1β cytokine trap, were studied previously in phase 2 trial involving patients with
منابع مشابه
Rilonacept (arcalyst), an interleukin-1 trap for the treatment of cryopyrin-associated periodic syndromes.
138 P&T® • March 2009 • Vol. 34 No. 3 INTRODUCTION Cryopyrin-associated periodic syndromes (CAPS) comprise a group of rare inflammatory diseases that are inherited in an autosomal dominant pattern. Male and female offspring are affected equally with varying degrees of severity. CAPS comprise three syndromes: familial cold auto-inflammatory syndrome (FCAS), Muckle–Wells syndrome, and neonatalons...
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Recurrent pericarditis is a common complication of acute pericarditis (15-30%) for which, in most cases, no underlying etiology is found [idiopathic recurrent pericarditis (IRP)]. IRP is currently viewed as an autoinflammatory disease with characteristic recurrent episodes of sterile inflammation. According to the most recent Guidelines, the initial treatment regimen consists of a combination o...
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It occurs in 15% to 32% of cases and the cause of the recurrence is usually unknown, although in some cases it may be traced to viral infection or may be a consequence of coronary artery bypass grafting1. The optimal method for prevention has not been fully established; accepted modalities include nonsteroidal anti-inflammatory drugs, corticosteroids, colchicines, immunosuppressive agents, and ...
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e read with interest the paper by Raatikka et al. (1) that gives us useful piece of information regarding pericarditis in children. he data are relevant, particularly regarding the good long-term utcome, with no instance of constriction, in agreement with our xperience in adults. We would like to comment on some tatements regarding therapy. The authors in fact conclude that orticosteroids, meth...
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BACKGROUND Colchicine seems to be a good drug for treating recurrences of pericarditis after conventional treatment failure, but no clinical trial has tested the effects of colchicine as first-line drug for the treatment of the first recurrence of pericarditis. METHODS A prospective, randomized, open-label design was used to investigate the safety and efficacy of colchicine therapy as adjunct...
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ژورنال
عنوان ژورنال: The New England Journal of Medicine
سال: 2021
ISSN: ['0028-4793', '1533-4406']
DOI: https://doi.org/10.1056/nejmoa2027892